Endocrine Abstracts

Objective: Altered hearing function in diabetic patients has been found in both pure tone audiometry and otoacoustic emissions (OAEs). We intended to evaluate the cochlear function with both DPOAE and TEOAE in patients with DM without polyneuropathy and hypertension.Patients and methods: Study group consisted of type 2 diabetic patients and healthy control group consisted of healthy age and sex matched volunteers. Detailed ear examination, pure tone audi...

Insulin resistance is one of the feature of obesity. Fetuin A is inhibitor of insulin receptor which belongs the family of receptor tyrosine kinase. It has been observed that fetuin-null mice are resistant to diet-induced obesity and they exhibit increased insulin sensitivity. Increased production of reactive oxygen species is suggested to be associated with insulin resistance. Attacks of reactive oxygen species to DNA results in base oxidation. Among the oxidized bases, 8-hyd...

Introduction: The growth promoting effects of GH and IGF1 has lead to increasing number of cancer surveillence studies in acromegaly so far. We herein aimed to present the prevalance of cancer in acromegaly patients followed in our institution.Patients and design: We retrospectively analyzed medical records of 151 patients with acromegaly (83 females) followed in our department from 2001 to 2012.Results: Overall, cancer was detecte...

Objective: We aimed to evaluate the prevalance of thyroiditis in ankylosing spondylitis patients in this study. We investigated the role of serum procalcitonin as a chronic inflamatory marker in ankylosing spondylitis.Methods: Sixty-seven patients who diagnosed as ankylosing spondylitis according to American College of Rheumatology (ACR) criteria and 57 healthy controls were included in our study. Serum levels of procalcitonin, TSH, free triiodothyronine...

Introduction: The evidence shows that the prevalence of metabolic syndrome is increased in patients with hypogonadism. However, much of the data regarding this association comes from the elderly patients with obesity, hypertension or type 2 diabetes. The total testosterone levels alter physiologically in these conditions and thus can falsify the association. We aimed to investigate the prevalence of the metabolic syndrome in young adults with hypogonadism who do not have any c...

Objective: Hypopituitary patients receiving convensional hormone substitution, but without growth hormone (GH) replacement, have an increased mortality from cardiovascular disease. The aim of the present study was to assess the heart rate variability(HRV) in hypopituitary patients with severe GH deficiency.Material and method: Thirty-five patients (20 women, 15 men, aged 23-75 years) with severe GH deficiency, all of 35 patients with low insulin-like gro...

The high-density lipoprotein (HDL) levels are decreased in paitents with hypogonadotropic hypogonadism (HH). Although testosteron regulates lipoprotein metabolism, the effect of testosterone replacement therapy on HDL metabolism is not clearly shown in HH. The aim of this study is to determine the effects of testesterone replacement on HDL subfractions in young patients with HH. Forty-three cases with HH (mean age 21±2.45 years) were enrolled. Fifty-one healthy volunteer ...

Data regarding cardiovascular risk in subjects with non-functioning adrenal adenoma is limited. The aim of this study is to investigate osteoprotogerin (OPG) and Interleukin-6 (IL-6) levels in subjects with non functioning adrenal incidentalomas.Of 51 subjects without findings of hypercortisolism or other adrenal gland disorders (AI), 32 BMI-unmatched controls (C) and 20 BMI-matched controls (BC) were enrolled. Participants underwent hormonal evaluation ...

It has been previously shown that adrenal adenomas are associated with a variety of metabolic disturbances like glucose intolerance and obesity. The aim of this study is to demonstrate the risk of non-alcoholic fatty liver disease development in subjects with adrenal incidentalomas.Among 302 subjects referred between 2001 and 2008 for the evaluation of incidentally discovered adrenal mass, 150 subjects with appropriate data were included. Computed tomogr...

Adrenal adenomas are characterised with metabolic disturbances. The aim of this study is to demonstrate the changes in some metabolic and anthropometric parameters after 24 months follow up in subjects with non-functioning adrenal adenomas.Subjects referred between 2001 and 2008 for the evaluation of adrenal tumours were included. Computed tomography (CT) was the initial radiological intervention. Initial hormonal evaluation included 1 mg or 2 day 2 mg d...